Indianapolis is known as the "Crossroads of America" for a good reason. Interstates 65, 69, 70, and 74 meet here. The city's outer belt is I-465. Travel directly through the city on I-70 or I-65. Direct travel using I-74 or I-69 is not possible; I-74 is routed around the center of the city on I-465, and I-69 currently ends at its intersection with I-465 to the city's north.
Indianapolis International Airport (IATA: IND)  is about 15 minutes from downtown without traffic.
Greyhound located right in the heart of the city. 350 S Illinois St., +1 317 636-6666.
Burlington Trailways travels only throughout the Midwest. +1 800-992-4618.
Megabus Indianapolis' downtown stop location for departures and arrivals is located at the megabus.com stop and IndyGo Bus Shelter at 200 E Washington Street on the north side of Washington Street between Delaware and Alabama Streets. Wheelchair accessible. Fares from $1 when reserved very far in advance.
Amtrak runs daily between Chicago and Indianapolis.350 S. Illinois St. +1 800-872-7245.  Three days a week between Indy and Washington, D.C. & New York City. Located right in the heart of the city.
Travel within the city
Currently there are two pedicab companies serving downtown Indianapolis area, one is Indy Pedicabs and the other is Circle City Pedicabs. They provide downtown area taxi service, downtown touring service, wedding service and special events. The former has a slightly larger service area than the latter, and it provides free taxi service within its service area while the latter charges $5 minimum for taxi service.
Indy Go is the public bus system. It travels throughout the city and suburbs. Single fares are $1.75, day passes are available for $4, and all buses are equipped with two bike-racks. The bus system is a very nice way to travel with the one exception of frequency—outside of rush hour routes, you can find yourself with a 30+ minute wait. Almost all routes travel from a locality in the outskirts of the city to the centrally-located bus stops downtown and back out; there are also a handful of smaller circulators and loops.
Cabs are readily available mainly downtown and in Broad Ripple Village.
Travel information provided by Wikitravel.